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Genetic Predisposition can be a Reason for Smoking

For the majority of smokers giving up their habit is an enormous challenge, but for some of them kicking down smoking may be especially hard, since their addiction could be partly caused by genetics, several latest researches found out.

One of these researches, published last week in online journal Nature Genetics discovered that human body has three genes related with the amount of tobacco consumed each day.

“One of the genes was related with taking up smoking and the other is linked with the ability to give up smoking,” stated Helena Furberg, the University of North Carolina professor and the research co-author. She said that they found genetic versions on chromosome 15, which were linked with chain smoking, located together with nicotine receptor genes. Other studies have related those versions with nicotine addiction.

The discovery resulted from an analysis of phenotypes of 74,053 people.

The scientist added that more analyses have to be carried out in order to pass that discovery to the clinic; however, in the long-term perspective the scientists could use the findings to predict the impact of various smoking cessation therapies on the ability to successfully give up smoking.

The second research was carried out by Oxford University research team, analyzed phenotypes of nearly 40,000 people for genes responsible for consuming tobacco. The group discovered a group of genes chromosome 15 linked to the amount of cigarettes burnt each day.

Dr. Clyde Franks, leader of that research, admitted that taking into consideration genetic factor of nicotine dependency should have a considerable impact on public health in the future.

And the third research, which was done by the University of Iceland research group, as well analyzed human genes to discover certain genes related to smoking. Basing on the information collected from almost 70,000 current smokers, the research showed that genes on chromosome 15 were closely associated with tobacco consumption. The scientists also discovered two genes involved in the process of nicotine metabolism and another two genes linked in the response by the body to the use of nicotine.

The American Lung Association consultant Dr. Norman H. Edelman admitted the findings gives evidence to the data confirming that smoking can be explained by genetic factor as well as external factors, like environment and presence of smoking friends.

Nevertheless, Dr. Edelman mentioned that he doubts the discovery could change the current smoking cessation treatments; however, it could help in raising the public awareness about smoking.

“The majority of both smokers and non-smokers consider that smoking is a sort of a self-imposed issue,” Edelman added. “But the scientific evidence shows that some smokers have to struggle with genetic factor, in order to quit their habit.

The scientists also said that the results of those studies would help to establish a picture of the factors impacting on smoking initiation and ability to give up the habit; however, it also brings a difficult task for the scientists, which is to create treatments to help genetically predisposed smokers to quit smoking and live a healthier life.